Inhibitory Effects of Curcumin on the Expression of NorA Efflux Pump and Reduce Antibiotic Resistance in Staphylococcus aureus
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چکیده
منابع مشابه
Effects of synthesized iron oxide nanoparticles from Ziziphora clinopodioides on expression of the efflux pump genes of Staphylococcus aureus
Introduction: One of the important factors causing nosocomial infections is drug-resistant Staphylococcus aureus strain, so correspondingly, having norA efflux pump is one of the bacterial's ability to generate drug resistance. Iron has been used as a nanoparticle with antimicrobial activity against bacteria. The aim of this study was to investigate the effect of iron oxide nanoparticles synthe...
متن کاملThe Effect of Thyme (Thymus vulgaris) Extract on the Expression of norA Efflux Pump Gene in Clinical Strains of Staphylococcus aureus
The NorA efflux pump considered as one of the contributors to antibiotic resistance in Staphylococcus aureus strains. One of the challenges of the researchers is finding natural plant compounds with the ability to inhibit the pumps. The aim of this study was to investigate the inhibitory effect of thyme (Thymus vulgaris) extract on NorA efflux pump in ciprofloxacin-resistant strains of S. aureu...
متن کاملEffect of Artemisia ciniformis Extract on Expression of NorA Efflux Pump Gene in Ciprofloxacin Resistant Staphylococcus aureus by Real Time PCR
Background: Activity of norA efflux pump is one of the antibiotic resistance mechanisms in ciprofloxacin resistant Staphylococcus aureus. In this study, the effect of Artemisia ciniformis extract on reducing the expression of norA efflux pumps gene in ciprofloxacin-resistant Staphylococcus aureus isolates was studied. Materials and Methods: Ciprofloxacin resistant S. aureus isolates, were trea...
متن کاملevaluation of expression of nora efflux pump in ciprofloxacin resistant staphylococcus aureus against hexahydroquinoline derivative by real-time pcr.
staphylococcus aureus causes a wide variety of infections worldwide. methicillin-resistant s. aureus is one of most common causes of nosocomial and community acquired infections. the fluoroquinolones are an important class of antibiotics that used to treat infections caused by s. aureus. today, a significant increase in the rate of ciprofloxacin resistance in methicillin-resistant s. aureus str...
متن کاملCapsaicin, a novel inhibitor of the NorA efflux pump, reduces the intracellular invasion of Staphylococcus aureus.
OBJECTIVES To delineate the role of capsaicin (8-methyl-N-vanillyl-6-nonenamide) as an inhibitor of the NorA efflux pump and its impact on invasion of macrophages by Staphylococcus aureus. METHODS Capsaicin in combination with ciprofloxacin was tested for activity against S. aureus SA-1199B (NorA overproducing), SA-1199 (wild-type) and SA-K1758 (norA knockout). The role of NorA in the intrace...
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ژورنال
عنوان ژورنال: Journal of Pure and Applied Microbiology
سال: 2018
ISSN: 0973-7510
DOI: 10.22207/jpam.12.1.12